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Published patents relating to drug delivery to the central nervous system
Patent (registration) numbers are shown where granted; otherwise the application number is shown, marked “(appl.)”. European patents validated in several countries under one EP number are listed as “Europe”.
| Patent | Country | Patent (reg.) no. / Application no. |
|---|---|---|
| Delivery of a Gene Therapy Vector to the Brain by Convection-Enhanced Delivery | United States | 8,901,077 |
| Delivery of a Therapeutic Agent to the Cerebral Cortex by Administering a Viral Vector by Convection-Enhanced Diffusion | Europe | EP 2997150 |
| United States | 9,700,587 | |
| Method of Treating a CNS Disorder Using a Water-Soluble Histone Deacetylase Inhibitor | United States | 10,278,954 |
| A Biologically Inert Fluid for use in the Treatment of a CNS Disorder | Europe | EP 3833394 |
| United States | 12,453,784 | |
| PCT | PCT/GB2019/052187 (appl.) | |
| Method (gene therapy into the brainstem) | Canada | 3290058 (appl.) |
| Europe | 24728280.9 (appl.) | |
| Japan | 2025-565948 (appl.) | |
| United States | 19/483419 (appl.) | |
| PCT | PCT/GB2024/051221 (appl.) | |
| United Kingdom | 2306952.9 (appl.) | |
| Method (gene therapy to muscle) | United Kingdom | 2109503.9 (appl.) |
| United Kingdom | 1906912.9 (appl.) | |
| United Kingdom | 2009981.8 (appl.) | |
| PCT | PCT/GB2022/051690 (appl.) |
| Patent | Country | Patent (reg.) no. / Application no. |
|---|---|---|
| Improved Catheter Positioning for Parkinson's Disease Treatment | United States | 10,369,329 |
| United States | 11,160,954 | |
| United States | 12,168,103 |
| Patent | Country | Patent (reg.) no. / Application no. |
|---|---|---|
| Method and Apparatus for Fluid Delivery | United States | 10,518,075 |
| A Fluid Connector for Fluid Delivery Apparatus | United States | 7,984,929 |
| Europe | EP 2012866 | |
| Neurosurgical Instruments / Neurological Apparatus (3-tube system / cannula) | Europe | EP 2601997 |
| China | 201310092806.3 (appl.) | |
| United States | 9,452,241 | |
| United States | 10,857,327 | |
| Neurological Apparatus Comprising a Percutaneous Access Device | Europe | EP 2086607 |
| Europe | EP 2974756 | |
| United States | 8,974,422 | |
| United States | 10,751,520 | |
| United States | 11,717,663 | |
| Percutaneous Drug Delivery Apparatus | Europe | EP 2533830 |
| Japan | 5801323 | |
| Japan | 6151320 | |
| United States | 8,827,987 | |
| United States | 10,596,362 | |
| United States | 11,826,536 | |
| Europe | 21156072.7 (appl.) | |
| Implantable Fluid Router (cannula with gas filter) | Europe | EP 2533829 |
| United States | 10,507,316 | |
| China | 201180009002.1 / 201510612697.2 (appl.) | |
| Neurosurgical Apparatus (ventricular shunt) | Europe | EP 2763736 |
| United States | 10,610,674 | |
| Drug Storage Apparatus (drug dosing tubing) | Europe | EP 2812065 |
| Drug Delivery Apparatus / Connector Device for Drug Delivery Apparatus (admin port) | Europe | EP 2812066 |
| Japan | 6392670 | |
| Japan | 6812390 | |
| Europe | EP 3398647 | |
| United States | 10,086,187 | |
| Neurosurgical Apparatus (guide tube in recess in skull) | Europe | EP 2819739 |
| United States | 11,129,643 | |
| Canada | CA 2864624 | |
| Cranial Drill System (drill set) | Europe | EP 2854660 |
| Europe | EP 3332718 | |
| Japan | 6475160 | |
| Japan | 6983745 | |
| Canada | CA 2874792 | |
| United States | 10,363,049 | |
| United States | 16/444089 (appl.) | |
| Neurosurgical Apparatus and Methods (recessed step catheter) | Europe | EP 2877108 |
| China | 201380044196.8 (appl.) | |
| Japan | 6334524 | |
| Canada | CA 2879770 | |
| United States | 10,751,513 | |
| United States | 18/430389 (appl.) | |
| Neurosurgical Device and Method (port with legs) | Europe | EP 2903681 |
| China | 201380051627.3 (appl.) | |
| Canada | CA 2886048 | |
| United States | 9,662,484 | |
| India | 484975 | |
| Neurosurgical Apparatus (fluted catheter) | Europe | EP 3119310 |
| United States | 11,154,377 | |
| United States | 11,559,371 | |
| Percutaneous Access Apparatus (cartridge-based port) | United States | 11,638,811 |
| Europe / China / PCT | 17723498.6 (appl.) | |
| Stereotactic Device (animal adaptor) | United Kingdom | GB 2532695 |
| Method (HDACi) | United Kingdom | 1601773.3 (appl.) |
