Neurochase CED Drug Delivery System

The Neurochase CED System

The Blood Brain Barrier prevents many therapeutics accessing the brain. Even if overcome, many therapies require effective doses to be confined to specific brain targets.

Currently available devices and methods of delivering therapies directly to brain targets are complex and time consuming with successful delivery dependent on individual surgeons level of skill.

We believe the Neurochase CED system drastically reduces procedure times with a simple, safe and highly scalable process.

The Device is for investigational use only at the moment, not for use in clinic.

Animation of how a catheter is implanted into a specific target area of the brain using the Neurochase system

Advantages of The Neurochase System

Fast

Insertion and fixation of each flexible cannula can be achieved within 10 minutes. Rapid removal under local anaesthetic.

Accurate

Novel probe design with micro-dissector facilitates precise targeting of deep brain structures. Devices delivered through guide hub inserted within the skull

Safe

We belive there is less risk of human error, less time under GA, less trauma to brain, less risk of infection, less risk of cannula displacement, less risk of wrong dosing or contamination with biohazardous therapy. Cannula infusions in awake patients facilitate neurological assessment and modulation of infusions.

Simple

Insertion with fewer steps, no setting of multiple tools to scales, delivery of individualised volumes per catheter with standard pump settings.

Effective

Highly effective reflux control and distribution allowing for incredibly accurate dosing to targeted treatment volumes.

Scaleable

We believe we have a simplified work flow that does not require experts to deliver devices. Implantation accomplished with widely available stereotactic frames and robots. Short surgical time to insert multiple devices and then infuse them simultaneously in awake patients enables more effective use of theatres and staff, greatly reducing costs. Devices easily removed under LA. Purpose built facilities for scalable delivery are at the advanced planning stage.

Workflow

A patient undergoing an operation using the Neurochase system should experience the following workflow.

Planning MRI Scan

The planning MRI scan is done as an outpatient.

Surgery

Patient admitted to ward.

Transfer to theatre for general anesthetic (GA).

On table registration with plan.

Cannula Implantation (10 mins per cannula).

On table confirmation of catheter placement.

Patient to recovery (awake).

Infusions

Simultaneous infusions with patients free to relax, read, watch TV etc.

Infusions monitored with MRI and neuro observations

Cannula removal

With local anesthetic

Overnight for observation

Patient Returns Home

The NeurochaseDrug Delivery System